WE
NEED YOUR HELP! Both samples of
affected and healthy dogs are still
needed. The
study's veterinarian researchers currently
have 80 affected dogs and 60 older healthy
dogs and would like to have 120 of each to
make our study be successful.
Please
participate in this
study if you:
1-Have a dog
that has just been diagnosed with
osteosarcoma, or your vet suspects
osteosarcoma. If a beloved
Rottweiler is diagnosed with
osteosarcoma (bone cancer), it is a
heartbreaking, oftentimes
life-shattering event. Your
participation in this study may not only
help future dogs receiving this
diagnosis with improved treatment
options, but may help in creating a test
for the gene that predisposes dogs to
obtaining osteosarcoma.
2-Have
a dog who is 8 years or older, healthy
and has never been diagnosed with
cancer, to be able to compare
the genome of affected and healthy
dogs. We will need an AKC number
or a copy of the pedigree through the
grandparents.
TO
PARTICIPATE
-
Request
a collection kit from us at the
address below.
-
Take
your dog to his own veterinarian to
have a blood sample drawn.
-
Send
the samples and paperwork back to
us.
If
you live east of the Mississippi
The Dog Genome
Project
Broad Institute of Harvard and MIT
One Kendall Square, Bldg. 300
Cambridge, MA 02139
617-252-1900
(phone)
617-252-1902
(fax)
dog-info@broad.mit.edu (email)
|
If
you live west of the Mississippi
Kenine
E Comstock, Ph.D.
University of Michigan
5121 Cancer Center
1500 E Medical Center Dr.
Ann Arbor MI 48109
734-647-7417
(phone)
734-647-5470
(fax)
keninec@med.umich.edu (email)
|
If your dog has been diagnosed with
osteosarcoma, the study's medical scientists will need:
If
you have a healthy dog of 8 years or
older, the study's medical scientists will need:
|
STUDY/GRANT SUMMARY
Eight thousand to 10,000 cases of bone
cancer, also known as osteosarcoma, are reported
in dogs in the United States annually,
representing a very significant health concern.
Sadly, in the majority of cases, spread of the
tumor through the body and death follows within
a few years. Osteosarcoma affects all dogs, but
the disease frequency is considerably higher in
large and giant breeds, including Rottweilers.
It has been suggested that genetics may play an
important role in this disease.
Our group of scientists have initiated a
project to identify the genetic risk factors for
osteosarcoma. This study is a collaboration
between University of Michigan, the Broad Institute
at MIT and Dr. Jaime Modiano at University of
Colorado. We expect that this study should lead
to improvements in treatment of osteosarcoma. In
addition, our findings will allow the
development of genetic tests for osteosarcoma.
We are collecting blood samples from
Rottweilers that have been diagnosed with
osteosarcoma. We do need a copy of the pathology
report describing how the diagnosis was made. We
are requiring a biopsy be done for the study.
Contact us prior to having the biopsy done and
we can give specific instructions. We also need
a copy of the pedigree through the grandparents.
Those fortunate owners with healthy dogs can
also help. In addition, we are collecting blood
samples from healthy dogs who are over 6 years
old and have never been diagnosed with cancer.
Again, we need a copy of the pedigree through
the grandparents. Participating dogs should not
be related as far back as their grandparents, so
please don't send any you know to be related.
To participate in the study, Rottweiler
owners can simply request a collection
kit from us, take their dog to their own
veterinarian to have the blood samples drawn,
and then send the sample back to us . If
you would like to request a kit or any
further information about the study or
collection process, feel free to contact the
primary study scientist:
Kenine E Comstock, Ph.D
University of Michigan
5121 Cancer Center
1500 E Medical Center Dr.
Ann Arbor MI 48109
734-647-7417 (phone)
734-647-5470 (fax)
THANK
YOU FOR YOUR PARTICIPATION.
|
Rottweiler
Health Foundation Mission Statement
